Control of membrane integrity is critical for ensuring process efficacy in terms of microbial removal. Various monitoring techniques, such as turbidity, particle counting, and air testing are commonly used in membrane operation. However, membrane integrity is not necessarily reflected by a change of the permeate quality, i.e. turbidity as well as particle count. Therefore, the Acoustic Integrity Monitoring (AIM) was developed to monitor the integrity of the membrane especially when other techniques such as particle counting are not applicable. Based on hydrophonic sensor technology, the acoustic monitoring technique consists of measuring the noise due to a compromised filter. The advantage of a hydrophonic sensor is that integrity of the membranes is monitored continuously during filtration. Moreover, the AIM is able to detect a non-cut compromised fiber with a hole of 0.5 mm and therefore, guarantees more than 6 log removal of viruses.