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Notes that the entire field of smoke toxicology is only about 25 years old. A series of key technical facts underpins much of today's thinking. Covers those facts, how they emerged, their implications, the spin-off disciplines to which they have given rise, and how they have shaped the current issues in this field. Discusses patterns of fire fatalities, technical issues, toxicological results, flashover, smoke toxicity in large fires, fractional effective dose, approaches to expressing toxic potency and control of materials.