ASHRAE 90.1 is one of the most prominent energy standards for buildings except Low-rise residential buildings. It provides minimum design and construction requirements for most types of Residential and Commercial buildings and their systems. In Table 5.5 -- 1 to 8, ASHRAE 90.1 provides values for building envelope requirements such as wall, roof, and glazing for various climatic zones. Also, In Table 6.8.1 -- 1 to 13 it provides the minimum efficiency requirements for various listed air-conditioning equipments. It is often found that the values provided in these tables are not pertinent to Middle Eastern regions considering its different geographical locations, climatic conditions, building practices, local regulations and cultures. Certain values of ASHRAE 90.1 standards are often found to be less stringent than the local authority regulations and standard practices prevailing in the region. The heat transmission through building envelope forms a significant portion of the cooling and heating loads for buildings and therefore a considerable percentage of energy consumption for the air-conditioning systems. Similarly, energy efficiency of equipments also substantially impacts the energy performance of air-conditioning equipments. Optimising the building envelope values and energy efficiencies of equipments can provide remarkable savings in energy and help in improving the energy performance of a building. The objective of this conference paper is to analyse and assess, some of the building envelope values such as wall, roof, glazing and energy efficiency in ASHRAE 90.1-2013 and other Middle Eastern regulations, using building energy modelling simulation techniques for different regions. A comparative analysis is made for thermal transmittance (U) values of walls, roof, glazing, solar heat gain coefficient (SHGC) and energy efficiency, based on the results from building energy modelling simulation, to assess the energy consumption and energy savings potential and obtain optimised values for these parameters relevant to the Middle Eastern region. Analysis is made using ASHRAE 90.1-2013 values against corresponding values from local regulations such as Ministry of Electricity & Water (MEW) Kuwait, Saudi Building Code (SBC-601), Dubai Municipality Regulations (DM) and Kharamaa, Qatar, to form a wider spectrum of climatic regions. The optimised values of building envelope components and energy efficiency of systems and equipments can significantly improve and enhance the energy performance of a building and help in sustainable and efficient buildings design in the Middle Eastern region.