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This document has been prepared to allow toxicological evaluation of the unregulated contaminant 2,4-pentanedione in drinking water, as an extractant from one or more drinking water system components evaluated under NSF/ANSI 61 (2014), or as a contaminant in a drinking water treatment chemical evaluated under NSF/ANSI 60 (2014). Both non-cancer and cancer endpoints have been considered, and risk assessment methodology developed by the U.S. Environmental Protection Agency (U.S. EPA) has been used.