This paper will review the status worldwide on technical and policy search for next-generation refrigerants with both low Global Warming Potential (LGWP) and low Life Cycle Climate performance (LCCP) with focus on stationary refrigeration applications. Synthetic HFO blends and natural refrigerants offer potential solutions in all applications, but all involve trade-offs among Global Warming Potential (GWP), efficiency, safety, and cost. With increasing concerns about energy prices and the desire for higher efficiencies, there is even more pressure in finding a Low-GWP refrigerant solution that is affordable and can sustain efficiency and reduce charge requirement. Theoretical analyses and test results from drop-in compressor and system tests will be present along with LCCP analysis for typical US stationary refrigeration applications and recommendations made for the path forward.