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ISO 21482:2007 specifies the symbol to warn of the presence of a dangerous level of ionizing radiation from a high-level sealed radioactive source that can cause death or serious injury if handled carelessly. This symbol is not intended to replace the basic ionizing radiation symbol (ISO 361), but to supplement it by providing further information on the danger associated with the source and the necessity for untrained or uninformed members of the public to stay away from it.

This symbol is recommended for use with International Atomic Energy Agency (IAEA) Category 1, 2, and 3 sealed radioactive sources. These sources are defined by the IAEA as having the ability to cause death or serious injuries.