This paper suggests a parametric design workflow of an institution building in New Orleans, Louisiana based on parametric, climate-based analysis. This workflow is aimed to support the early design process with passive strategies to enhance occupant thermal comfort and daylight conditions of the building as well as its energy efficiency. By analyzing the hot and humid climate of New Orleans and the needs of muliple spatial programs, including open spaces, workplaces, and residential units, parametric models were generated to simulate the annual thermal comfort and daylight conditions, which provides grounds for comparison among parametric models. In response to the climate analysis and bioclimatic strategies, three design steps were implemented: self-shading, façade components, and multi-functional screens.