Integrating Building Energy Modeling (BEM) and Computational Fluid Dynamic (CFD) early in the design process provides comprehensive information to design teams to select the optimum HVAC system in terms of thermal comfort. This paper is a review of previous CFD studies and also evaluates the thermal comfort inside a multipurpose arena bowl by using CFD analysis of the HVAC air-side system with different configurations using the IES Virtual Environment (IES VE) software. The challenges of this process and the software are addressed. Lastly, the integrated BEM is modified based on the optimized system solution and energy saving results over the baseline are presented.