This guide for Centralized Protection and Control (CPC) systems addresses the realization of various protection, automation and control functions within a CPC system utilizing data collected from intelligent electronic devices. This guide includes all protection, automation and control functions in a substation including interconnecting circuits using devices and their interconnections with suitable communication protocols. This guide includes references to existing standards applicable to protection, automation and control applications for various types of circuit elements such as generators, transformers, bus bars, shunt and series capacitor banks, reactors, transmission lines and distribution lines. The guide addresses CPC system architectures for typical substation configurations. The guide addresses the reliability and maintainability of each architecture, along with their respective testing requirements. The guide also addresses CPC development, installation, commissioning, troubleshooting and maintenance.