The present study reports the experimental comparison of cooling duty and pressure drop of ice slurry (Green Secondary Refrigerant) with chilled water. Experiments were performed on plate heat exchanger (PHE) using chilled water and ice slurry as secondary fluids. Propylene Glycol (PG) and Mono Ethylene Glycol (MEG) are used as depressants (10%, 20%, 30% and 40% concentration) in ice slurry formation. The results show that By using ice slurry in place of chilled water in plate heat exchanger, cooling duty found to be higher and pressure drop is slightly higher in case of ice slurry. Cooling duty of ice slurry increases with increase in antifreeze concentrations 10%, 20%, 30% and 40%. By using ice slurry in plate heat exchanger cooling duty was found to increased by 50% at 0.3m³/h (300 LPH) and increased by 37 % at 3.0 m³/h (3000 LPH) of 10% ice crystal PG ice slurry and pressure drop increased by 10% at 0.3m³/h (300 LPH) and increased by 7 % at 3.0 m³/h (3000 LPH).