Dehumidification is a highly energy intensive process, especially in humid climates and for building typologies that require strict space humidity setpoints. Sub-cooling of air to condense out moisture using chilled water or refrigerant is the most common method for dehumidifying. Alternative strategies such as desiccant wheel, dual wheel and wrap around coils could more energy efficiently be used for certain climate zones and project types. Using energy models and results from a customized Excel-based tool, this paper evaluates applicability of each dehumidification strategy based on the local climate and building typology.