According to the EIA, about 40 EJ of the total U.S. energy consumption was consumed by residential and commercial buildings in 2017, which is about 39% of the total 2017 annual U.S. energy consumption (EIA 2018). The potential for energy savings and greenhouse gas emissions reduction in existing buildings today remain largely untapped and that there is still much left to explore in respect to determining the best protocols for reducing building energy consumption on a national and even a global scale. The present work investigates the effectiveness of integrating an initial virtual screening to the conventional, hands-on, energy audit processes to more quickly and less costly obtain the potential energy savings for high energy consumption buildings. The virtual screening tool takes advantage of a customized energy efficiency management program and the readily available building energy consumption data to identify the buildings that have the highest energy savings potential and should be given priority for performing onsite walkthroughs, detailed energy audits, and the subsequent implementation of the identified energy conservation measures (ECM’s). By applying the proposed procedure to a group of buildings, the results of this study demonstrated that a combination of the software-based screening tools and a detailed experimental/onsite energy audit as necessary can effectively take advantage of the potential energy consumption and carbon footprint reduction in existing buildings today.