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There are several factors that affect the hygiene in the surgical operating theatres. The HVAC airside system plays an important role to maintain the adequate hygiene level in the operating theatres to prevent recirculation of infectious airborne contaminants. The present work utilizes a numerical modelling technique to predict local flow pattern, turbulence and age of airborne particulates profiles. To reduce the infection possibilities of the surgery staff and patients, one should reduce the backward flow from the polluted zones towards the clean zones and the recirculated zones; also, the air infection by direct and indirect ways should be avoided. The present paper introduces suitable design of the HVAC airside system that is based on application of 'the centralized partially ceiling supply flow' with the two extract levels to ensure the hygiene of the occupancy of the operating theatres.