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Technical Guide 1004 expands the coverage of sequential sampling introduced in ISO 14644-1. By applying sequential-sampling procedures in lieu of standard sampling procedures, significant savings of sampling time, perhaps as much as 80 percent, can be achieved when classifying the cleanliness of very clean air in cleanrooms and clean zones. The procedure is most appropriate for environments having air cleanliness that qualifies as ISO Class 4 or cleaner when tested in accordance with ISO 14644-1.