In recent years there has been rapid growth of RF technology to support wireless communication and data transport, as evidenced by the growing use of personal communication devices (e.g., mobile phones, WiFi enabled laptop computers). The incorporation of RF technology into PoC medical devices for wireless data transport has the potential to offer significant benefits to healthcare, although there are many issues that need to be understood and managed in order to ensure data transfer to computer servers, healthcare professionals, terminal data collection units, or other medical devices is accurate, efficient and reliable. Specific recommendations are aimed at different stakeholder groups that make up the audience for this guidance document including healthcare providers, medical device manufacturers / vendors, wireless equipment manufacturers / vendors, and relevant agency groups. The different functionality and operating environment of medical devices is addressed, ranging from core hospital equipment providing complex waveform and other physiological data to single parameter, low data rate sensors worn in a mobile health scenario. Further, patients, healthcare workers, medical equipment, and medical data move across different areas of the healthcare topology and necessitate that data track in a seamless and managed manner. Quality of Service (QoS) requirements (e.g., priority, throughput, latency) can vary significantly across different medical data types (e.g., alarms, real time wave forms, chart data, asset tracking, e-prescriptions), and simultaneous transport of different data types on a shared IT infrastructure are considered for the design of appropriate solutions. Other issues associated with operation on standardized "open" networks are security and privacy. Coexistence becomes a significant issue as a growing number of medical devices from multiple manufacturers, perhaps using multiple technologies (e.g., IEEE 802.15.1(tm) with IEEE 802.11b(tm)), start to crowd the RF spectrum and compete for bandwidth and channel access. Other issues considered include EMI/EMC, cost, power consumption, and technology configurability. Several factors influence the performance of the wireless system itself, including whether it operates on a shared IT network (e.g., WLAN, WWAN) or simply maintains a point-to-point connection. The former example is especially important when considering the operation of multiple medical devices from different manufacturers, each with different QoS requirements. An overall effort to promote plug-and-play (PnP) operability between commercially available medical devices and wireless systems (i.e., IEEE, ISO, ANSI, ITU-R, ITU-T), is supported in this guidance document, as well as in follow-on IEEE 11073 profile standards. As private homes are increasingly outfitted with wireless networks, and home- and mobile- management of healthcare and chronic conditions becomes increasingly common, additional issues may emerge. Recommendations provided in this document are not prescriptive, but instead offer general guidance aimed at the different stakeholders to facilitate design and management of wireless medical data transport to support the necessary QoS and performance requirements as well as co-exist in a complex environment with other wireless traffic. Likewise, exercises and comparisons included in this document are not intended to endorse any particular medical device, wireless technology, or data exchange format, but to offer examples for reference and comparison. Ultimate solutions will vary greatly depend greatly on healthcare needs, resources, sizes, and environments.