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Biologics facilities for pilot, clinical trial, and manufacturing applications have special testing and balancing requirements. The testing and balancing function can ensure the integrity of the design intent through start-up; it provides valuable test data for clean room certification and validation while providing the owner long-term mechanical system reliability. One of the most important functions of the heating, ventilating, and air-conditioning (HVAC) systems in these facilities is the maintenance of differential pressures between rooms. A testing and balancing procedure to accomplish this is not addressed effectively by NEBB or AABC standards. A detailed specification of the testing and balancing procedures and incorporation of all system design data in the testing and balancing contract package is essential to the ultimate success of the project. The pressure differential instrumentation furnished and installed by the controls contractor should be calibrated during the testing and balancing activity. A final verification of the system performance by the engineer must be conducted prior to beginning clean room testing and certification activities.

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Citation: Symposium, ASHRAE Transactions, vol. 105, pt. 1