Supermarkets are major consumers of electrical energy. The presence of refrigerated cases in supermarkets makes moisture removal the primary air-conditioning requirement. Hybrid desiccant cooling systems have been proposed as an alternative to conventional vapor compression systems as a means of reducing electrical energy consumption and energy costs. This paper studies the performance of three possible hybrid system configurations in supermarket applications and compares their performance with the traditional vapor-compression system. Results presented suggest a total air-conditioning savings of 60% with hybrid systems for the design condition considered.