Growing concerns about the global warming impact of hydrofluorocarbons (HFCs) or fluorocarbon refrigerants (F-gases) are driving the development of new regulatory actions to restrict and lower the direct global warming potential (GWP) impact of many refrigerants. These demands have resulted in the development a whole new class of F-gases called unsaturated fluorocarbons, commonly referred to as hydrofluoroolefins or olefin HFCs. These next generation fluids do not affect the ozone layer and have very low GWP as compared to those being targeted for replacement in the market. These new olefin HFCs are being blended with existing HFCs to obtain lower GWP replacements for existing HFC blends. One example in this class of Olefin HFC/HFC blends, R452A, is being considered for a number of refrigeration applications, especially those in which compressor discharge temperature is a primary concern. This paper will provide an overall assessment of the application of the new Olefin HFC/HFC blend refrigerant R452A in trailer, truck, and marine container refrigeration equipment. R452A provides specific environmental and safety features of interest including: no impact to stratospheric ozone, more than 50 percent lower GWP (R452A GWP = 1945 compared to R404A GWP = 3943), low toxicity, and non-flammability equal to R404A. The paper will also review system performance characteristics relative to R404A. The LCCP emission profiles of R404A, R407A, and R407F will be compared to R452A. Reliability indicators will be provided, such as material compatibility, chemical stability, and field trial experiences.