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API Publication 4261 summarizes information from the technical literature on producing and applying alcohols and ethers as fuels and fuel components for the transportation sector. It assesses the technical advantages and disadvantages of alcohols and ethers with respect to hydrocarbon fuels. Since the amendment of the Clean Air Act in 1977, and subsequently in 1990, public interest in the role of oxygenates in transportation has significantly increased. This edition of API Publication 4261 has been updated and expanded to include a review of the oxygenate regulations and the technical literature that has been published since 1988. It provides a technical assessment suitable for policy discussions related to alcohols and ethers in transportation.