These guidelines offer guidance on bridge design for human-induced extreme events. It provides information on the response of concrete bridge columns subjected to blast loads, as well as blast-resistant design and detailing guidelines and analytical models of blast load distribution. The guidelines include discussion on how to potentially reduce risk of other structural bridge components (e.g., bridge towers, cable stays, suspender ropes), as well as other intentional hazards to consider for threat vulnerability risk assessments (nonexplosive cutting devices, collisions or impacts, and fire). This second edition includes additional resources for identifying potential solutions to mitigate risk from other intentional hazards. This 2022 2nd edition supersedes the first edition, published in 2011.