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This discussion addresses questions of possible mutagenicity, carcinogenicity, and teratogenicity relative to exposure to tetrachloroethylene (PCE) in drinking water. The author highlights results of mutagenicity, carcinogenicity, and teratogenicity studies of PCE. Results of these studies indicated that there is no convincing evidence that PCE is a mutagen or teratogen. Carcinogenicity studies indicate that a lifetime exposure of 9 to 35 ppb PCE would increase the risk of cancer by 1 in 100,000 persons. However, the accuracy of this prediction is not verifiable. Includes 14 references.