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Full Description

ISO Guide 35:2006 gives statistical principles to assist in the understanding and development of valid methods to assign values to properties of a reference material, including the evaluation of their associated uncertainty, and establish their metrological traceability. Reference materials (RMs) that undergo all steps described in ISO Guide 35:2006 are usually accompanied by a certificate and called a certified reference material (CRM). This Guide will be useful in establishing the full potential of CRMs as aids to ensure the comparability, accuracy and compatibility of measurement results on a national or international scale. In order to be comparable across borders and over time, measurements need be traceable to appropriate and stated references. CRMs play a key role in implementing the concept of traceability of measurement results in chemistry, biology and physics among other sciences dealing with materials and/or samples. Laboratories use these CRMs as readily accessible measurement standards to establish traceability of their measurement results to international standards. The property values carried by a CRM can be made traceable to SI units or other internationally agreed units during production. ISO Guide 35:2006 explains how methods can be developed that will lead to well established property values, which are made traceable to appropriate stated references. It covers a very wide range of materials (matrices), ranging from gas mixtures to biological materials, and a very wide range of properties, ranging from chemical composition to physical and immunoassay properties.
 

Document History

  1. ISO Guide 35:2017


    Reference materials - Guidance for characterization and assessment of homogeneity and stability

    • Most Recent
  2. ISO Guide 35:2006

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    Reference materials - General and statistical principles for certification

    • Historical Version
  3. ISO Guide 35:1989


    Certification of reference materials -- General and statistical principles

    • Historical Version