This study investigates the performance of a ceiling mounted personalized ventilation (PV) system when assisted with chair-mounted fans. Detailed computational fluid dynamics (CFD) simulations were performed to study the velocity, temperature, and CO 2 fields around the microclimate of the occupant. The CFD model was integrated with a validated bio-heat model to determine the corresponding segmental skin temperature and local and overall comfort and sensation. The CFD model was validated experimentally using a thermal manikin in a climatic chamber. Segmental skin temperature, velocity field, and CO2 field were validated experimentally. The predicted values and the measured values showed relatively very good agreement. This study revealed that he chair fans configuration to achieve best thermal comfort and best IAQ occurred at different fan heights. The fan height and flow rate for best thermal comfort were 40 cm above floor level and 10 L/s, respectivelyThe use of chair mounted fans permitted achieving energy savings up to 17% when compared with conventional mixing ventilation system.