The purpose of this guide is to describe a basic framework (i.e., the program elements, guidelines on implementation, element interaction, and their scope of application) directed at improving nuclear generating station and other nuclear facility performance through the effective implementation of reliability programs. It is oriented toward facility availability, encompassing balance-of-plant and safety equipment. Effective implementation of these guidelines should also improve facility safety by reducing challenges to safety systems in addition to enhancing reliable operation of the components of those safety systems.