This paper presents a method that can be used by a single system or a group of systems to evaluate disinfection options for compliance with new disinfection byproducts regulations. The following general steps need to be followed in this type of evaluation using a water treatment plant simulation model: obtain up-to-date information on recent developments in disinfection and treatment technologies, which are specifically applicable to the system being analyzed along with their unique constraints; perform a preliminary analysis of the technologies that might be suitable for implementation by its member agencies; and, determine one or more alternatives that could be viable based on paper evaluation and conduct experimental evaluation to narrow the selection. A generic example is presented in the paper. Includes figures.