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The effects of fouling on the cross-flow ultrafiltration of a natural water are modeled in both the constant pressure and constant flux operational modes. Semi-empirical equations are derived which accurately predict the various flows and pressures in an ultrafiltration system when used to treat both a raw groundwater and a groundwater pretreated with powdered activated carbon. The effects of both reversible and irreversible fouling are modeled, and the overall efficiency of water production is compared for the constant flux and constant pressure modes.