This paper summarizes the results of a Health Effects Study (HES). The HES represents the product of a substantial research effort to estimate the potential health risk associated with reclaimed water relative to an existing raw water supply to the City. The study included elements for identifying, characterizing, and quantifying infectious disease agents and potentially-toxic chemicals, and for screening mutagenicity and bioaccumulation of the chemical mixtures present, in both the treated wastewater and the City's untreated potable water supply. The untreated water supply represented by raw water entering the Miramar water treatment plant. The study also included a reliability analysis, using data from the technical performance evaluation of unit processes in the demonstration water reclamation plant. Also, the evaluation included conducting an epidemiology study to collect baseline data of the San Diego population and conducting a chemical risk assessment on both water. A summary of the results from each of the study elements is presented.