This paper compares four of the most basic air-conditioning systems. Moreover, the systems compared are floor FCUs versus VRV and ceiling FCUs combined with an independent air duct network versus air duct network with CAUs. The comparison is madeaccording to economical, functional, technical, and convenience criteria. After a brief reference to the three ways in which air-conditioning systems can be categorized, there are some conclusions drawn froman air-conditioning study conducted for an industrial facility. Finally, the best systems are chosen for the air conditioning of this facility.