This publication is intended for the suppliers, distributors, and users of arsine and its handling equipment. This publication includes guidance for design of equipment, cylinders and valve usage, handling controls and safety. Guidelines on the operational steps associated with the use of arsine and arsine mixtures as well as fire protection, gas detection, ventilation, and related safeguards are also included. The manufacture, purification, and analysis of arsine are beyond the scope of this document, although the general guidance given is also relevant to these processes.