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This chapter includes a review of the fundamentals of UV-C energy’s impact on microorganisms; how UV-C lamps generate germicidal radiant energy; various components that comprise UV-C devices and systems; and a review of human safety and maintenance issues. Terminology GUV Fundamentals Germicidal Ultraviolet Sources and Equipment UV-C LEDs UVC Photodegradation of Materials Maintenance Safety Installation and Commissioning Unit Conversions